It is the two-step synthesis of aspirin starting from oil the experiment differs in three ways from traditional aspirin synthesis experiments for general chemistry. Aspirin synthesis may also include an additional step, in which wintergreen oil (methyl salicylate) is converted into salicylic acid (figure 2) this helps students to gain an understanding about multi-step synthesis and the idea of transforming a naturally occurring substance into a therapeutically valued product. Synthesis of aspirin and oil of wintergreen - free download as pdf file (pdf), text file (txt) or read online for free. In this experiment, both methyl salicylate (oil of wintergreen) and acetylsalicylic acid (aspirin) were synthesized with the use of salicylic acid as an alcohol, salicylic acid reacts with acetic anhydride to form acetylsalicylic acid, which is a white, powdery solid. Experiment 19: synthesis of aspirin and oil of wintergreen the purpose of this lab was to synthesize the organic compounds, aspirin and oil of wintergreen, through the process of esterification between an alcohol and an acid these are compounds that contain a hydroxyl group and carboxyl group respectively. Therefore during the synthesis of the aspirin some of the aspirin will be converted back to starting material to help push the reaction toward the products, one could distill off the acetic acid this is because the reduction of the products will cause more starting material to react to regain equilibrium.
Austin peay state university department of chemistry chem 1121 synthesis of aspirin and oil of wintergreen revision f8 page 5 of 7 data sheet. Reminder: these notes are meant to supplement, not replace, the laboratory manual synthesis of aspirin notes history and application aspirin is one of the most commonly used drugs in the world with approximately 100. Aspirin, or acetylsalicylic acid (asa), is a derivative of salicylic acid (sa) that is used as an analgesic (reduces and prevents pain) and antipyretic (reduces or prevents fever) medication it is probably the most commonly used over-the-counter medication. Nsf ccli project page 1 experiment oil of wintergreen: synthesis and nmr analysis o introduction: when salicylic acid reacts with methanol in the presence of.
The synthesis of aspirin the synthesis of oil of wintergreen in the last esterification reaction the phenolic group ( ) of salicylic acid was attacked in this esterification reaction the carboxylic acid group ( ) from salicylic acid is attacked. Petroleum product of the week: aspirin sarah chemical structure and came up with better methods of synthesis oil but the “oil” in aspirin isn’t.
Aspirin (2nd edition) compiled by david lewis edited by colin osborne and maria pack designed by imogen bertin and sara roberts first published by the royal society of chemistry in 1998. Experiment 22 synthesis of aspirin and oil of wintergreen goals: in this two-week experiment the important area of organic chemistry will be illustrated by the preparation and characterization of two compounds. Acetylsalicylic acid is an ester formed by reaction of the -oh group of salicylic acid with the -cooh group of acetic acid the more acid part of salicylic acid (in other words, its own -cooh group) is not part of the ester reaction, even though its presence may cause confusion to students.
Preparation of acetylsalicylic acid (aspirin) background one of the most widely used nonprescription drugs is aspirin figure 5: the aspirin synthesis. Esterification: the synthesis of aspirin (asa) methyl salicylate, for example, is oil of wintergreen, isopentenyl acetate is oil of banana or pear.
New lab manual: synthesis of aspirin with a difference in this lab manual, ‘synthesis of aspirin’ (oil of wintergreen). The full balanced molecular equation for the salicylic acid synthesis is c 8 h 8 o 3 + 2 naoh in the synthesis of salicylic acid from wintergreen oil.
Methyl salicylate is a naturally occurring chemical that is obtained from winter green oil that can be used to synthesize after the synthesis of aspirin. Aspirin –biological activity • analgesic (painkiller) • antipyretic (fever reducer) • anti-inflammatory (inhibition of the synthesis of prostaglandins) • side effects: gastric irritation, bleeding. Examples include drugs, synthetic fabrics, paints, plastics, etc synthesis of aspirin and methyl salicylate the two compounds we will be preparing, aspirin (acetylsalicylic. It is the two-step synthesis of aspirin starting from oil of wintergreen the mechanism for this synthesis provides examples of three major classes of chemical reactions: hydrolysis, condensation, and proton transfer. Experiment 4 organic lab study play title synthesis of salicylic acid from wintergreen oil lab objective heating under reflux synthesis of aspirin from.